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The early career researchers of the Collaborative Research Centre 1451 "Key mechanisms of motor control in health and disease" are proud to invite you to Cologne for a two-day exciting symposium: 10 distinguished speakers from around the world, and a unique opportunity for presenting your work and networking with peers. Check the program for more info and sign up before it is too late!
The meeting will take place in the MTI Building (Center for Medical Biochemistry, University Building 44b) that is located in Köln-Lindenthal between the University Hospital of Cologne (Uniklinik), the CECAD Research Center, the Center for Molecular Medicine Cologne (CMMC) and the Max Planck Institute for Ageing.
Access to the MTI Building is possible by going either through the CECAD passage (Joseph-Stelzmann-Straße 26) or through the Center for Molecular Medicine Cologne passage (Robert-Koch-Straße 21).
The Collaborative Research Centre 1451 "Key Mechanisms of motor control in health and disease" brings together neuroscientists investigating genetic factors, cellular, and synaptic as well as systems/neural network processes underlying motor control in animals and humans, in both health and neuropsychiatric diseases.
All investigators are committed to the CRC’s multi-faceted, iterative, and integrative agenda with the long-term goal of identifying the essential mechanisms underlying normal and pathological motor control.
A critical challenge for the sensorimotor system is managing the intricate coordination of dozens of limb muscles to interact with the world with speed and dexterity. Despite the importance of sensory feedback for effective movement, delays in the transmission of peripheral signals imply an additional more rapid internal feedback mechanism. A prominent theory posits that outgoing motor commands are copied to the cerebellum, where they are used to generate predictions of impending movement outcomes that can be used to compensate for sensory delays and rapidly update motor output. Yet how putative copy signals are functionally organized as they enter the cerebellum, and how cerebellar output refines motor output remain poorly understood. In two projects we are combining molecular, anatomical, electrophysiological, behavioral, and modeling approaches in mice to define the functional organization of: a) major efference copy inputs to the cerebellum that convey ongoing movement information; and b) discrete cerebellar output pathways that provide rapid routes for influencing motor neuron activity to facilitate refinement and enable dexterity.